Species Human Entrez 6921 | Human Mouse Ensembl ENSG00000154582 | |
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Aliases ELOC, SIII, eloC, TCEB1, transcription elongation factor B subunit 1 External IDs MGI: 1915173 HomoloGene: 38083 GeneCards: ELOC | ||
Transcription elongation factor B polypeptide 1 is a protein that in humans is encoded by the TCEB1 gene.
Contents
Function
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
Interactions
TCEB1 has been shown to interact with: