Species Human Entrez 10010 | Human Mouse Ensembl ENSG00000136560 | |
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Aliases TANK, I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator External IDs MGI: 107676 HomoloGene: 3081 GeneCards: TANK | ||
TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.
Contents
Function
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
TANK (gene) has been shown to interact with TANK-binding kinase 1, IKBKE, TRAF2, IKBKG and TRAF3.