Species Human Entrez 6877 | Human Mouse Ensembl ENSG00000148835 | |
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Aliases TAF5, TAF2D, TAFII100, TAF(II)100, TAFII-100, TATA-box binding protein associated factor 5 External IDs MGI: 2442144 HomoloGene: 5064 GeneCards: TAF5 | ||
Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.
Contents
Function
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex.
Interactions
TAF5 has been shown to interact with: