Entrez 9015 | Ensembl ENSG00000143498 | |
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Aliases TAF1A, MGC:17061, RAFI48, SL1, TAFI48, TATA-box binding protein associated factor, RNA polymerase I subunit A External IDs MGI: 109578 HomoloGene: 4155 GeneCards: TAF1A | ||
TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.
Contents
Function
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.
Interactions
TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A and Protein SET.
References
TAF1A Wikipedia(Text) CC BY-SA