Species Human Entrez 6950 | Human Mouse Ensembl ENSG00000120438 | |
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Aliases TCP1, CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha, T-complex 1 External IDs MGI: 98535 HomoloGene: 5656 GeneCards: TCP1 | ||
T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene.
Contents
Function
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
Interactions
T-complex 1 has been shown to interact with PPP4C and HDAC3. CCT also directly interacts with lectin type oxidized LDL receptor-1 (LOX-1) while its ligand oxidized low density lipoprotein (OxLDL) disassociates CCT from LOX-1.