Girish Mahajan (Editor)

T arm

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
T arm

The T-arm or T-loop is a specialized region on the tRNA molecule which acts as a special recognition site for the ribosome to form a tRNA-ribosome complex during protein biosynthesis or translation (biology).

The T-arm has two components to it; the T-stems and the T-loop.

  • There are two T-stems of five base pairs each. T-stem 1 is from 49-53 and T-stem 2 is from 61-65.
  • The T-loop is also often known as the TΨC arm due to the presence of thymidine, pseudouridine and cytidine residues. tRNA is the only RNA species that contains the nucleoside thymidine.

    • Organisms with T-loop lacking tRNA exhibit a much lower level of aminoacylation and EF-Tu-binding than in organisms which have the native tRNA.

    In Mammalian DNA, telomeric repeat-binding factor 2 or TRF2 has been found to remodel linear telomeric DNA into large T-loops.

    References

    T arm Wikipedia
    (Text) CC BY-SA