Systems pharmacology

Systems pharmacology (drug network) is the application of systems biology principles to the field of pharmacology. It seeks to understand how medicines work on various systems of the body. Instead of considering the effect of a drug to be the result of one specific drug-protein interaction, systems pharmacology considers the effect of a drug to be the outcome of the network of interactions a drug may have. In 1992, the article on systems medicine and pharmacology by B.J. Zeng was published in China, at the National Conference on Chinese and Western Medicine. Networks of interaction may include chemical-protein, protein–protein, genetic, signalling and physiological (at cellular, tissue, organ and whole body levels). Systems pharmacology uses bioinformatics and statistics techniques to integrate and interpret these networks.

Contents

• Matthias machacek systems pharmacology with small data
• Quantitative and systems pharmacology approaches for the development of oncology drugs
• References

Mini-review of network-based prediction of novel drug targets.

Systems pharmacology can be applied to drug safety studies as a complement to pharmacoepidemiology. The EU-ADR has successfully incorporated systems pharmacology into their signal substantiation pipeline.