Rahul Sharma (Editor)

Stibophen

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ATC code
  
P02BX03 (WHO)

PubChem CID
  
16683091

Formula
  
C12H4Na5O16S4Sb

Molar mass
  
769.12 g/mol

CAS Number
  
23940-36-5

ECHA InfoCard
  
100.041.752

3D model (Jmol)
  
Interactive image

Pubchem
  
16683091

Stibophen httpsuploadwikimediaorgwikipediacommons99

Stibophen is an anthelmintic classified as antimony compound and used as treatment of schistosomiasis by intramuscular injection.

Mechanism of action

Stibophen inhibits the enzyme phosphofructokinase, which the worms need for glycolysis, at least partly by binding to the sulfhydryl (–SH) group of the enzyme. Inhibiting glycolysis paralyzes the worms, which lose their hold on the wall of mesenteric veins and undergo hepatic shift, die, and are phagocytosed by liver cells.

References

Stibophen Wikipedia