ATC code P02BX03 (WHO) PubChem CID 16683091 Formula C12H4Na5O16S4Sb Molar mass 769.12 g/mol | CAS Number 23940-36-5 ECHA InfoCard 100.041.752 3D model (Jmol) Interactive image Pubchem 16683091 | |
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Stibophen is an anthelmintic classified as antimony compound and used as treatment of schistosomiasis by intramuscular injection.
Mechanism of action
Stibophen inhibits the enzyme phosphofructokinase, which the worms need for glycolysis, at least partly by binding to the sulfhydryl (–SH) group of the enzyme. Inhibiting glycolysis paralyzes the worms, which lose their hold on the wall of mesenteric veins and undergo hepatic shift, die, and are phagocytosed by liver cells.
References
Stibophen Wikipedia(Text) CC BY-SA