Standardization in Lab Automation

Mission

SiLA is the global initiative to standardize software interfaces in the field of life science research instrumentation. Instigated by the pharmaceutical industry's need for flexible laboratory automation, the initiative is supported by major device and software suppliers worldwide.

Background

Understanding the mechanisms of life requires extensive, often repetitive, experimentation. Laboratory automation, therefore, has become instrumental to the progress of the life sciences. Industry provides commercial laboratory devices to perform increasingly sophisticated tasks. However, combining equipment from different providers to work in concert often proves impossible. Exporting captured data from proprietary software for further analysis can be frustrating or impossible. This situation leads to a waste of resources: Available equipment needs to be replaced for compatibility reasons, software drivers have to be purchased or developed, and data conversion is time consuming. Such technical obstacles also limit the complexity of integrated laboratory robotic platforms, and thereby impede the development of higher level autonomous experimentation systems. SiLA enables researchers to focus on their scientific questions by reducing equipment connectivity effort to a minimum. This is achieved by using proven, tested and maintained documentation and code.

History

Advancements seen on the home consumer electronics marked like USB or UPnP triggered the idea of applying a similar approach to the laboratory automation environment. Why was it possible to easily upload pictures from any digital camera on any computer but in the same time not even thinkable to replace a lab device (e.g.: a Shaker) of one brand with a Shaker of a different brand? Analyzing the situation led to the conclusion that the incompatibility was a result of missing interface definitions. The idea of a standardized interface based on the Common Command Set (CCS) concept was born.

Membership

SiLA has formed a not-for-profit membership organisation. SiLA requires members to pay annual membership dues. Details on membership classes and related fees can be found here.

Organisation Structure

SiLA is a not-for-profit membership corporation with global footprint. Membership is open for institutions, corporations and individuals active in the life science lab automation industry. The SiLA consortium provides professional training, support and certification services to suppliers and system integrators implementing SiLA compliant interfaces.

Scope of Standardization

The SiLA foundation of standards addresses control and data interfaces between devices and process management, LIMS and Enterprise Systems.

SiLA Standards

SiLA has developed and released a detailed technical specification of the SiLA Device Control and Data Interface Specification (DCDIS) and a Common Command Library. The development of the SiLA Data Capture Standard, a standardized format for meta data and result data from microplate readers, has reached the final phase.

A paper describing these three standards in details is under preparation for publication in JALA.

Device Interface Standard

The SiLA device interface standard covers all ISO/OSI levels of the device control interface from physical to application layer. The interface standard is based on web service/SOAP communication with the devices. Commands are generally executed in asynchronous manner with an immediate response and a delayed event after completion of the command processing or after an error. Error recovery procedures are also supported and the general behavior of the devices is managed by a state machine. The state machine enables also complex behaviors like parallel processing of commands and command queuing. By supporting three different integration levels, SiLA provides a unique, standardized interface between lab automation devices and process management systems so that also legacy devices can be integrated in SiLA compliant systems. SiLA compliance can be achieved by providing native, directly embedded SiLA device interfaces or by software only SiLA drivers and/or interface converters. The SiLA Device Control and Data Interface Standard eases and accelerates the integration and adaptation of systems through generic Device Class Interfaces providing Common Command Sets.

Common Command Dictionary

By grouping devices of the same functionality device classes can be created. SiLA Common Command Sets define commands for these device classes. SiLA defines the command names, the number of parameters and their names as well as the return data. Since commands and parameters are described in the WSDL documentation tag of the commands web service, a process management software (PMS) can automatically generate a list available commands for each device. So far SiLA has defined about 30 device classes and a command library with about 100 commands. Commands range from mandatory commands that are needed to make transitions in the state machine, over required commands for the specific device class, to optional commands for which not every device in the device class might provide the functionality. In addition guidelines for the implementation of supplier-specific device commands and parameters are provided. Some commands are applicable for almost every device class. For example, the commands SetParameter, GetParameter, ExecuteMethod are widely used. Also PrepareForOutput and PrepareForInput are common because they enable the transport mechanisms to transfer labware items from device to device. The mandatory commands include operations like Reset, Initialize, Abort and Pause. In addition also locking a device for exclusive use is provided.