St. Xavier's College functioned as an evening Intermediate Science from the premises of St. Xavier's School, Jawalakhel, Lalitpur in the initial years, and later moved to its own building at Maitighar, Kathmandu, in 1993. For the first eight years the only course offered was Intermediate in Science, in affiliation with Tribhuvan University. In 1996 the three-year Bachelor of Science in Social Work, the first of its kind in Nepal, was established in conjunction with Kathmandu University. In 1997 a B.Sc. in Environmental Science was offered but after three years discontinued admitting students. Since then bachelor's degrees have been added in Business Studies and Physics in 2002, in Information Management in 2003, and in 2007 in Computer Science and Information Technology, Microbiology, and B.A. in English, Journalism and Social Work. In 2007 also five master's degree programs were established, in Physics, Microbiology, Business, Social Work, and English. In 2009 Higher Secondary School Level (+2) was initiated and in 2011 Cambridge A-levels.
The College moved to Maitighar Heights in 1988 and the first new building, the Academic Block, was built in 1993. The construction of the Administration Block was completed in 1998, followed by that of Watrin Hall and the Library Block in 2000. To cater to the needs of the two IT-based degree programs, and to provide all students with computer facilities, four computer laboratories were constructed, with a total of 203 internet-connected computers. The E.L. Watrin Memorial Building was built in 2005, linking the Academic Block with the Administration Block. A rooftop cafeteria was built in 2006. In 2009 a six-storey building housing modern laboratories for physics, chemistry, botany, zoology, and microbiology and social studies
Today, the College has approximately 3000 students coming from 275 schools representing all 75 districts and almost all the ethnic, linguistic, and cultural diversity of Nepal. One of the innovative outreach programs is the Partnership in Education (PIE) established in 2004. PIE works in partnership with government schools for the development of the academically weak students in the lowest income brackets, accommodating approximately 300 students annually.
A typical admission profile of St. Xavier's can be correlated to their admission criteria for intermediate programmes (grades 11 and 12) which is extremely competitive. Every year more than 13,000 students from throughout Nepal apply and around 500 students are enrolled. In 2012 of the 685 selected 520 enrolled, with a median GPA of 3.9/4.0. The admission process includes a preliminary cutoff score at the School Leaving Certificate national exam – equivalent of GCSE, an analytic Multiple Choice examination, and an interview with college personnel.
For the first eight years the college had offered an Intermediate in Science course. Bachelor's and master's level courses affiliated with Tribhuvan University and Kathmandu University have been running other courses as well. In the year 2009, Intermediate in Science was terminated and Higher Secondary Level (+2) science stream was initiated in affiliation with the Higher Secondary Education Board, Nepal. The college has completed its sixth year of the +2 program with facilities including a well-equipped laboratory, library, cafeteria, and basketball court. The Higher Secondary Level (+2) science program has offered only two sub-streams: Biology and Physics. All the students of +2 science study a similar combination of five subjects (physics, chemistry, biology, mathematics, and English) in grade XI and in grade XII biology students study physics, chemistry, biology, English, and Nepali, whereas physics students study physics, chemistry, mathematics, English, and Nepali.
The admissions for Plus Two generally begin on the month of June immediately after the School Leaving Certificate Examination's results are published.
Graduates in 2010-12 achieved 406 distinctions, 97 first division and 2 second division. In 2012, 1030 students (509 of 2011/13 & 521 of 2012/14) were studying +2 science (Grade XI & XII). All sat for the HSEB examination in 2013.
The college sponsors clubs and committees under the supervision of club-moderators, including the Physics Club,Literary Club, Art and Culture Club, SET council, Sports Club, Social Service Club and USM Committee for the development of leadership, teamwork, community service, and time management.
The GCE A-Levels started at St. Xavier's College from 2011 A.D. which is affiliated to the University of Cambridge International Examinations. The students are admitted on the basis of highly competitive entrance examinations. The students are highly encouraged here for independent course work. There are numerous facilities including well-equipped laboratory, library, cafeteria, and basketball court. The students at A-Levels Department are given their choice to select the subject to study. However, General Paper and Mathematics is mandatory to students. The courses offered are Physics, Chemistry Mathematics,Biology, Computer Science, Accounting, Economics, Business Studies, General Paper.
The students themselves have established St. Xavier's A-Level Society(SAS), which mobilizes the students for independent course work and a collaborative teamwork in addition to leadership. The students serve in the nearest social service site once a week as a community service. Moreover, the students are taken for the outstay camp away from their house to give a sense of service to others as the motto of College.
Generally, the admission is open for A-levels is earlier than for the +2 students. There are 120 students in each graduating class.
The undergraduate courses started after 8 years the college was established. As on 2016, there are 7 undergraduate and 3 graduate level courses.
The college encourages its students in undergraduate and graduate level to engage in activities through the establishment of club: UDAAN.
Many graduates pursue further studies abroad or at the country's top engineering institute (IOE), medical institute (IOM), or Ministry of Education, pursuing degrees in science, business, and the humanities. Some have studied in the USA, Canada, Australia, Germany, UK, Philippines, Japan, China, India, Pakistan, and Bangladesh.
The college set up its Alumni Association on its 25th year of its establishment in 2013. The Alumni Committee looks after and handles all the activities as the Alumni of St. Xavier's College, Maitighar.Hikes: Chandragiri (2016), Pilotbaba Ashram (2015), Phulchoki (2014), Champadevi (2013)
Strings for Smiles (2016, 2014) [in association with FocusEd Nepal]
Ride Against Cancer (2016, 2015) [in association with Richa Bajimaya Memorial Foundation]
Changa Chet (2013), नवक्षितिज: आशाका किरण (2015) [in association with USM club]
Alumni of SXC, a group in Facebook intended to unite all alumni in one place (2015)
SXC Alumni Day, a yearly event to gather alumni under the same place held on 25 December (2015, 2014, 2014 June)
Career Counselling: International Studies in US (2014)
Alumni Satellite Group