Samiksha Jaiswal (Editor)

Src inhibitor

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Src inhibitor

Src inhibitor is a class of inhibitors that targets src kinase family, which is transcribed by proto-oncogenes src genes (abbreviating for sarcome genes) that potentially induced cell of malignant transformation. Because of the crucial position of src gene/kinase in cells, src inhibitors may have prospect to be antineoplastic agents used for pancreatic cancer, breast cancer, stomach cancer et al.

Examples

  • KX2-391 is an oral src inhibitor and the first clinical inhibitor with GI50 of 9–60 nM in cancer cell lines.
  • Bosutinib has been developed for the treatment of chronic myelogenous leukemia by Pfizer.
  • Saracatinib, the first Src inhibitor to show inhibition of the Src pathway in human tumor tissue, has anti-tumor activity alone or in combination with chemotherapeutic agents.
  • PP1, PP2 are both inhibitors of Lck and FynT.
  • Quercetin
  • Dasatinib
  • References

    Src inhibitor Wikipedia


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