Spinelli is an Italian surname. Notable people with the surname include:
Altiero Spinelli (1907–1986), Italian advocate for European federalism and founding father of the European UnionAnthony Spinelli (1927–2000), American director of pornographic filmsAshley Spinelli, a character in the cartoon Recess.Damian Spinelli, a fictional character on the American soap opera General HospitalGiuseppe Spinelli (1694–1763), cardinal prefect of the Congregation for the Evangelization of PeoplesNiccola Spinelli (1865–1909), Italian opera composerJerry Spinelli (born 1941), American author