Spinelli is an Italian surname. Notable people with the surname include:
Altiero Spinelli (1907–1986), Italian advocate for European federalism and founding father of the European Union
Anthony Spinelli (1927–2000), American director of pornographic films
Ashley Spinelli, a character in the cartoon Recess.
Damian Spinelli, a fictional character on the American soap opera General Hospital
Giuseppe Spinelli (1694–1763), cardinal prefect of the Congregation for the Evangelization of Peoples
Niccola Spinelli (1865–1909), Italian opera composer
Jerry Spinelli (born 1941), American author
