The Southern Comfort Conference is a major transgender conference that has taken place annually since 1991. It features seminars, events, speeches by prominent people in the LGBT community, numerous vendors catering to transgender and transsexual people, and more, and is known as the largest, most famous, and pre-eminent such conference in the United States. The organization offers scholarships to some attendees.
The conference provided the title for and is featured heavily in the 2001 documentary Southern Comfort, about the life and death of Robert Eads, whose goal in 1998 was to live long enough to attend the conference. Eads succeeded, and his speech at the conference is featured in the documentary. In honor of the memory of Eads, the conference offers health exams through the annual "Robert Eads Health Project" in collaboration with the Trans Health Initiative at the Feminist Women's Health Center.
The conference has built a reputation as a safe place for LGBT people with a familial atmosphere, and aims at inclusiveness. It attracts people from all over the United States, offering the opportunity for social and other interaction. From the conference's founding in 1991 until 2014, the conference was held in Atlanta, GA. At the conclusion of the 2014 Southern Comfort Conference, the board of directors announced that SCC 2015-2017 will be held in Fort Lauderdale, Florida. It was announced by the BOD that, because of increased insurance costs due to unstated outcomes of a lengthy litigation, 2016 was the last Southern Comfort Transgender Conference (SCTC).