Species Human Entrez 6752 | Human Mouse Ensembl ENSG00000180616 | |
 | ||
Aliases SSTR2, Somatostatin receptor 2 External IDs MGI: 98328 HomoloGene: 37427 GeneCards: SSTR2 | ||
Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.
Contents
Function
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.
Interactions
Somatostatin receptor 2 has been shown to interact with SHANK2.
Therapeutic targeting
Most pituitary adenomas express SSTR2, but other somatostatin receptors are also found.< Somatostatin analogs (i.e. Octreotide, Lanreotide ) are used to stimulate this receptors, and thus to inhibit further tumor proliferation.