Sisson is a surname that appeared in rural England around West Riding, Yorkshire in the 15th century. DNA testing confirms a common link to an area known to this day as Soissons, France. Notable people with the surname include:
Bryan Sisson, American writer and applied anthropologist
C. H. Sisson, British writer
Edgar Sisson, purchaser of the infamous Sisson Documents
Fred Sisson, United States Representative from New York
Jeremiah Sisson (1720–1783), British instrument maker
John Richard Sisson, acting president of the Ohio State University
Jonathan Sisson (1690–1749), British instrument maker
Marshall Sisson, British architect
Rosemary Anne Sisson (born 1923), British writer and screenwriter
Roger Lee Sisson, (June 24, 1926 – January 22, 1992) technical computer pioneer
Rufus Sisson, American college basketball player
Septimus Sisson (1865-1924), professor and author of the standard veterinary work "Anatomy of the Domestic Animals"