Sisson is a surname that appeared in rural England around West Riding, Yorkshire in the 15th century. DNA testing confirms a common link to an area known to this day as Soissons, France. Notable people with the surname include:
Bryan Sisson, American writer and applied anthropologistC. H. Sisson, British writerEdgar Sisson, purchaser of the infamous Sisson DocumentsFred Sisson, United States Representative from New YorkJeremiah Sisson (1720–1783), British instrument makerJohn Richard Sisson, acting president of the Ohio State UniversityJonathan Sisson (1690–1749), British instrument makerMarshall Sisson, British architectRosemary Anne Sisson (born 1923), British writer and screenwriterRoger Lee Sisson, (June 24, 1926 – January 22, 1992) technical computer pioneerRufus Sisson, American college basketball playerSeptimus Sisson (1865-1924), professor and author of the standard veterinary work "Anatomy of the Domestic Animals"