Sisk is an Irish surname and has been found in East Cork since the 18th century. A modern version of the medieval surname Saghas of County Kildare.
The earliest form of Sisk is found in Tenby, Wales in 1405. Sayse, from Sais, a sobriquet meaning "Saxon".
People with the surname include:
Bernice F. Sisk, (1910–95) American Congressman
Doug Sisk (born 1957) Major League baseball player
Howard Sisk (c.1930–2001) aka "Curly Howard", American radio disc jockey
Jerry Sisk, Jr. (1953–2013) American gemologist and co-founder of Jewelry Television
John Sisk, (1837–1921) Irish builder, founder of the Sisk Group
John Sisk, Jr. (born 1941) American football player
Johnny Sisk (born 1906) American football player
Laura Wright née Laura Sisk (born 1970) American actress
Mark Sisk, (born 1942) Episcopal Bishop of New York
Mildred Gillars née Mildred Sisk (1900–88), nicknamed "Axis Sally", American broadcaster in Nazi Germany
Stephen J. M. Sisk (born 1966) Canadian actor -turned manager /studio designer
Tommie Sisk (born 1942) Major League baseball player
Wayne Sisk (1922-99), American soldier, portrayed in Band of Brothers miniseries
