Simeon is a surname. Notable people with the surname include:
Albert T. W. Simeons (1900–1970), leading exponent of a weight-loss protocol based on human chorionic gonadotropin (hCG)
Arthur Simeon (born 1983), stand-up comedian based in Toronto, Canada
Charles Simeon (1759–1836), English evangelical clergyman
Charles Simeon (colonist) (1816–1867), one of the members of the Canterbury Association who emigrated to Canterbury, New Zealand
Daphne Simeon, American psychiatrist
David Simeon (born 1943), British actor
Doris Simeon, award winning Yoruba and English actress
Eleazar b. Simeon, Jewish Tanna sage of the fifth generation
Eric Simeon (1918–2007), Indian school educationalist
George Simeon (fl. 1614–1624), English landowner and politician who sat in the House of Commons
Jay Simeon (born 1976), Canadian artist of Haida heritage
John Simeon (disambiguation)
José Simeón (born 1991), Spanish basketball player
Mbaydoum Simeon, member of the Pan-African Parliament from Chad
Omer Simeon (1902–1959), American jazz clarinetist
Richard Simeon, 2nd Baronet (1784–1854), English Liberal Party politician
Silvano Simeon (1945–2010), Italian discus thrower
Simeon baronets, two baronetcies created for persons with the surname Simeon
Xavier Siméon (born 1989), Grand Prix motorcycle racer from Belgium