Although Milestone had directed short training films for the U.S. War Department in 1918 and 1919, and acted as assistant director on the 1921 William A. Seiter film The Foolish Age, this was his feature film directorial debut.
Burglars Molly Brian (Marie Prevost) and Joe Hagney (John Patrick) break into the Vickers mansion on Long Island and loot the safe but are caught in the act by another crook, Jerry Winters (Clive Brook), who takes the money from them. The three are confronted by Pious Joe McDowell (Claude Gillingwater) and his wife Mamie (Mathilde Brundage), also crooks, but who assert themselves as friends of the Vickers family. Moly, Joe, and Jerry introduce themselves in turn as Vickers' household servants. A doctor (Dan Mason) arrives with his patient (Heinie Conklin) and quarantines the house. Unknown to the first five, the Doctor and patient are also crooks who use the ruse of a "quarantine" as part of their own methodology. During the brief quarantine, Molly ends up falling in love with Jerry and the two pledge to go straight. When the police (Fred Kelsey) finally arrive, Pious Joe takes responsibility for the robbery so that Molly and Jerry can escape.
Marie Prevost as Molly Brian
Clive Brook as Jerry Winters
John Patrick as Handsome Joe Hagney
Heinie Conklin as Scarlet Fever Sanders
Claude Gillingwater as Pious Joe McDowell
Mathilde Brundage as Mamie McDowell
Dan Mason as Doctor
Fred Kelsey as Policeman
The New York Times wrote the idea "has been worked out in an interesting fashion, with disappointing penitence as a closing touch," and that "picture is quite diverting, and it would have been even better if the humor were lighter in some sequences and if a touch of satire had been included at the finish."
The film was presumed lost when Jack Warner destroyed many of its negatives in the December 1948 due to nitrate film pre-1933 decomposition, but an announcement was made in May 2015 of its rediscovery in Queensland, Australia.
Restored version of Seven Sinners was shown in Queensland, Australia on February 19, 2017.
The film is planned released by Warner Bros. Home Entertainment.