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Medical vocabulary what does serotonin receptor agonists mean
A serotonin receptor agonist is a compound that activates serotonin receptors, in a manner similar to serotonin.
Contents
- Medical vocabulary what does serotonin receptor agonists mean
- 5 HT1A agonists
- 5 HT1B agonists
- 5 HT1D agonists
- 5 HT1F agonists
- 5 HT2A agonists
- 5 HT2B agonists
- 5 HT2C agonists
- 5 HT4 agonists
- 5 HT7 agonists
- References
Non-selective agonists: Psilocin and DMT are serotonin analogs found in certain plants or mushrooms. These compounds act on a variety of serotonin receptor types.
5-HT1A agonists
Azapirones such as buspirone, gepirone, and tandospirone are 5-HT1A agonists marketed primarily as anxiolytics, but also recently as antidepressants.
5-HT1B agonists
Triptans such as sumatriptan, rizatriptan, and naratriptan are 5-HT1B receptor agonists that are used to abort migraine and cluster headache attacks. Ergotamine also acts on this receptor.
5-HT1D agonists
In addition to being 5-HT1B agonists, triptans are also agonists at the 5-HT1D receptor, which contributes to their antimigraine effect caused by vasoconstriction of blood vessels in the brain. The same is true for ergotamine. Another 5-HT1D agonist is alnidita sumatriptan.
5-HT1F agonists
LY-334,370 was a selective 5-HT1F agonist that was being developed by Eli Lilly and Company for the treatment of migraine and cluster headaches. Development is slow however due to toxicity detected in animal test subjects.
5-HT2A agonists
Psychedelic drugs like LSD, mescaline, and 2C-B, act as 5-HT2A agonists. Their action at this receptor is responsible for their "psychedelic" effects. Some of these drugs, act as agonists for other 5HT receptor subtypes. Not all 5-HT2A agonists are psychoactive.
5-HT2B agonists
Drugs that act as agonists on this receptor are implicated in the progression of cardiac fibrosis. Fenfluramine, Pergolide and Cabergoline have been withdrawn from some markets for this reason. Some psychedelic drugs, including LSD and Psilocin, have been shown to activate this receptor directly. MDMA has been reported to be both a potent direct agonist and have an indirect effect by increasing plasma serotonin levels.
5-HT2C agonists
Lorcaserin is a thermogenic and anorectic weight-loss drug which acts as a selective 5-HT2C agonist.
5-HT4 agonists
Cisapride and Tegaserod are 5-HT4 partial receptor agonist that were used to treat disorders of gastrointestinal motility. Prucalopride is a highly selective 5-HT4 receptor agonist that can be used to treat certain disorders of gastrointestinal motility. Other 5-HT4 agonists have shown potential to be nootropic type drugs via promoting acetylcholine release.
5-HT7 agonists
AS-19 is a 5-HT7 receptor agonist that has been used only in research.