Inhibitory effect of serotonin antagonist on leukocyte endothelial interactions in vivo and in vitro
A serotonin antagonist is a drug used to inhibit the action at serotonin (5-HT) receptors.
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5-HT2A antagonists
Antagonists of the 5-HT2A receptor are sometimes used as atypical antipsychotics (contrast with typical antipsychotics, which are purely dopamine antagonists). They include:
5-HT2A/2C antagonists
5-HT3 antagonists
Another subclass consists of drugs selectively acting at the 5-HT3 receptors, and thus are known as 5-HT3 antagonists. They are efficacious in treating chemotherapy-induced emesis and postoperative nausea and vomiting. They include:
Other 5-HT3 antagonists are used for the treatment of irritable bowel syndrome:
Non-selective 5-HT antagonists
Please note, that although some non-selective serotonin antagonists may have an particular affinity for a specific 5-HT receptor (and thus may be listed above e.g. methysergide), they still may also possess a generalised non-selective action.