Serna is a surname. Notable people with the name include:
Alexis Serna (born 1985), American player of gridiron footballAndrea Serna (born 1977), Colombian model, TV presenter, reporter, and producerAssumpta Serna (born 1957), Spanish actressDarkin Serna (born 1993), Colombian footballerDiego Serna (born 1973), Colombian footballerDillon Serna (born 1994), American soccer playerElkin Serna, Colombian Paralympic marathon runnerEnrique Serna, (born 1959), Mexican author and screenwriterIsaac Serna, Peruvian politicianJoe Serna, Jr. (1939–1999), American civil rights activist and mayor of SacramentoJorge Horacio Serna (born 1979), Colombian footballerLéa Serna (born 1999), French figure skaterLily Serna (born 1986), Australian mathematician and television presenterMagüi Serna (born 1979), Spanish tennis playerMarcelino Serna (1896–1992), Mexican immigrant and United States Army soldierMarco Antonio Serna Díaz (1936-1991), Colombian herpetologist, ornithologist, and naturalistMauricio Serna (born 1968), Colombian footballerPatricio M. Serna, New Mexican Supreme Court JusticePaul Serna (born 1958), American baseball playerPepe Serna (born 1944), American film and television actor and artistRalph Serna (born 1957), American long-distance runnerRicardo Serna (born 1964), Spanish footballerSnooky Serna (born 1966), Filipina film and television actressSara Serna (born 1987), Spanish footballerViviana Serna (born 1990), Colombian actress and presenter