Serna is a surname. Notable people with the name include:
Alexis Serna (born 1985), American player of gridiron football
Andrea Serna (born 1977), Colombian model, TV presenter, reporter, and producer
Assumpta Serna (born 1957), Spanish actress
Darkin Serna (born 1993), Colombian footballer
Diego Serna (born 1973), Colombian footballer
Dillon Serna (born 1994), American soccer player
Elkin Serna, Colombian Paralympic marathon runner
Enrique Serna, (born 1959), Mexican author and screenwriter
Isaac Serna, Peruvian politician
Joe Serna, Jr. (1939–1999), American civil rights activist and mayor of Sacramento
Jorge Horacio Serna (born 1979), Colombian footballer
Léa Serna (born 1999), French figure skater
Lily Serna (born 1986), Australian mathematician and television presenter
Magüi Serna (born 1979), Spanish tennis player
Marcelino Serna (1896–1992), Mexican immigrant and United States Army soldier
Marco Antonio Serna Díaz (1936-1991), Colombian herpetologist, ornithologist, and naturalist
Mauricio Serna (born 1968), Colombian footballer
Patricio M. Serna, New Mexican Supreme Court Justice
Paul Serna (born 1958), American baseball player
Pepe Serna (born 1944), American film and television actor and artist
Ralph Serna (born 1957), American long-distance runner
Ricardo Serna (born 1964), Spanish footballer
Snooky Serna (born 1966), Filipina film and television actress
Sara Serna (born 1987), Spanish footballer
Viviana Serna (born 1990), Colombian actress and presenter