The term seizure threshold is used to describe the balance between excitatory and inhibitory forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be compliant with their anticonvulsant drug regimen.
Medications such as the antidepressant and nicotinic antagonist bupropion (Wellbutrin, Zyban) and the atypical opioid analgesics tramadol (Ultram, Ultram ER, Ultracet) and tapentadol (Nucynta, Palexia, TAPAL) can lower the seizure threshold. So can other factors, including:
Cancer and certain disorders of the nervous, cardiovascular and gastrointestinal systems can also influence the severity and frequency of seizures.