In 2005, Sanada tried to earn a training spot in the New Japan Pro-Wrestling (NJPW) dojo, but failed to pass an introductory test. Sanada took the test alongside future NJPW wrestlers Tetsuya Naito and Yoshi-Hashi. Afterwards, Sanada began looking to other promotions for a training school.
Sanada was eventually trained by Keiji Mutoh's All Japan Pro Wrestling (AJPW) affiliated Mutohjuku school and turned pro on March 13, 2007, in a losing effort teaming with Ryuji Hijikata against Katsuhiko Nakajima and T28. Within a few months into his career, Sanada won his first honor when he teamed with Kensuke Sasaki and Nakajima to win the Samurai! TV Triple Arrow Tournament on May 29, 2007. Following the tournament victory, Sanada spent the next two years in opening match wrestling other up-and-comers and began teaming with Manabu Soya. By 2009, Sanada began moving up the card as he took part in his first Champion Carnival but finished last with no points. Later in the year, Sanada broke up with Soya and briefly teamed up with Osamu Nishimura with the two entering the 2009 World's Strongest Tag Determination League with Sanada even getting a pinfall victory over the tag team champions: Taiyo Kea and Minoru Suzuki but the team's run ended when Sanada suffered the flu and had to withdraw from the tournament.
In 2010, Sanada once again entered the Champion Carnival but the results were the same as he finished last in his block with no points. By the spring, Sanada helped form the New Generation Force stable with Suwama, Masayuki Kono, Ryota Hama, and Manabu Soya. On August 29, 2010 at Pro Wrestling Love in Ryogoku Vol. 10, Sanada and Soya defeated Taru and Big Daddy Voodoo to win the All Asia Tag Team Championship. Sanada and Soya entered the 2010 World's Strongest Tag Determination League in the fall where they finished in 6th place with 7 Points. Sanada and Soya would lose the All Asia Tag Team Championship to Daisuke Sekimoto and Yuji Okabayashi on March 21, 2011. During the year 2011, Sanada reached his full potential by reaching the finals against Yuji Nagata, but loss to him in the finals. He also entered in 2011 World's Strongest Tag Determination League with Kai and won the tournament by defeating Masayuki Kono and Masakatsu Funaki in the Finals. They then challenged the All Japan World Tag Team Champions Dark Cuervo and Dark Ozz for a title shot but came up short. They then faced each other in a singles match, which led to Sanada winning that match. After the match they both had an interview and Sanada decided that they should part ways and move on with their Tag Team which Kai also agreed on. In 2012 he then challenged All Japan ace Suwama to a 60-minute match but also fell short in that match. He then challenged his former trainer Satoshi Kojima to match but also fell short after a Lariat by Kojima, during the Match he sustained a right knee injury but still wrestled and took a little time off to heal his knee. He then participated in 2012's Champion Carnival and lost to his former tag partner Manabu Soya. But he then won his first match against Manabu Soya's brother Takumi Soya and debuted a new finisher called "This Is It". On May 20, 2012, Sanada and Joe Doering defeated Soya and Takao Omori to win the World Tag Team Championship. Sanada and Doering lost the title back to Soya and Ōmori on June 17. On October 7, 2012, Sanada defeated Yasufumi Nakanoue in a tournament final to become the inaugural Gaora TV Champion. After reaching the semifinals of the 2013 Champion Carnival, All Japan announced on May 1, 2013, that Sanada would be leaving on a learning excursion to Moncton, Canada, where he would train under Emile Duprée. During the excursion, Sanada lost the Gaora TV Championship to René Duprée on May 27.
On July 1, while still in Canada, Sanada announced his resignation from All Japan, taking part in a mass exodus caused by Nobuo Shiraishi becoming the promotion's new president. Following his resignation, Sanada traveled to Mexico on his own expense to continue his training. Though Sanada was not announced as part of Keiji Mutoh's splinter promotion Wrestle-1, he did make a surprise appearance at the promotion's inaugural event on September 8, losing to Kai in a singles match. Sanada and Kai had a rematch in the main event of Wrestle-1's second show on September 15; this time Sanada was victorious. On September 24, Wrestle-1 announced that Sanada had signed a contract with the promotion. Sanada wrestled his first match under a Wrestle-1 contract on October 6, losing to Kai in the main event of the promotion's first event in Korakuen Hall. As a result, Kai won the series between him and Sanada 3-2. On November 16, Sanada unsuccessfully challenged visiting American wrestler A.J. Styles for the TNA World Heavyweight Championship.
In early 2014, Sanada was offered an opportunity to earn another shot at the TNA World Heavyweight Championship, but he instead opted to go for the TNA X Division Championship. On February 15, Sanada defeated nineteen other men in a battle royal to become the number one contender to the title. On March 2 at Kaisen: Outbreak, Sanada defeated Austin Aries to become the new TNA X Division Champion. The following day, Wrestle-1 announced Sanada would be leaving Japan to work for TNA indefinitely. Sanada continued making sporadic appearances for Wrestle-1, defending his X Division Championship against Seiki Yoshioka on March 22 and against Christopher Daniels on April 17, while also losing to The Great Muta in the main event of Wrestle-1's second Ryōgoku Kokugikan event, Shōgeki: Impact, on July 6. The following day, Wrestle-1 and Sanada held a press conference to announce that he had signed a contract with TNA, giving him a dual contract between Wrestle-1 and the American promotion.
Sanada returned to working for Wrestle-1 full-time in October 2014, when TNA went inactive for the rest of the year. The following month, Sanada teamed up with Hiroshi Yamato for the First Tag League Greatest tournament, set to determine the inaugural Wrestle-1 Tag Team Champions. The team finished their block with a record of one win, two draws and one loss, narrowly missing advancement to the semifinals. On December 22, Sanada unsuccessfully challenged Keiji Mutoh for the Wrestle-1 Championship. On May 13, 2015, Sanada held a press conference in Japan, where he announced that he was leaving Wrestle-1 once his contract expired two days later, so he could continue working in the United States full-time as a freelancer.
Sanada made his TNA debut on March 9 at Lockdown, where he, working under just his family name, teamed with The Great Muta and Yasu to defeat Chris Sabin and Bad Influence (Christopher Daniels and Kazarian) in a six-man tag team steel cage match. Four days later, Sanada made his Impact Wrestling debut, teaming with Tigre Uno to defeat TNA World Tag Team Champions The BroMans (Robbie E and Jessie Godderz), in a non-title match. As a result, the two received a shot at the TNA World Tag Team Championship the following week, but were defeated in a three-way match, which also included The Wolves (Davey Richards and Eddie Edwards). Sanada and Tigre Uno were then put against each other in a "best of three" match series for the TNA X Division Championship. On April 27 at Sacrifice, Sanada defeated Uno to win the series 2–1 and retain the X Division Championship. On June 15 at Slammiversary XII, Sanada defeated Crazzy Steve, Davey Richards, Eddie Edwards, Manik and Tigre Uno in a six-way ladder match to retain the X Division Championship. On the July 10 episode of Impact Wrestling, Sanada lost the X Division Championship back to Austin Aries.
On the July 24 episode of Impact Wrestling, Sanada took part in an angle, where he turned on his mentor The Great Muta, hitting him with a steel chair and a moonsault, after initially saving him from James Storm, turning heel in the process. The following week at Destination X, Storm introduced Sanada as his new protégé, before he defeated Brian Cage and Crazzy Steve to advance to the finals of a tournament for the vacant X Division Championship. On the August 7 episode of Impact Wrestling, Sanada was defeated by Samoa Joe in the finals of the tournament, which also included Low Ki. After signing a one-year contract with TNA, Sanada debuted the new ring name "The Great Sanada" and a look inspired by The Great Muta on the August 27 Impact Wrestling, defeating Austin Aries with help from Storm. Sanada and Storm were eventually joined by Abyss and Manik to form a stable named The Revolution. On October 12, Sanada main evented TNA's Bound for Glory event in Tokyo, teaming with Storm in a tag team match, where they were defeated by The Great Muta and Tajiri. On the April 10, 2015 episode of Impact Wrestling, Storm dismissed Sanada from The Revolution, stating that Sanada had let him down one too many times. Sanada's departure from TNA was confirmed by the promotion on April 16.
On September 20, 2014, Sanada, using his villainous Great Sanada persona, made his debut for American independent promotion Chikara, entering the annual Rey de Voladores tournament. After defeating Amasis, AR Fox and Orlando Christopher in his opening four-way elimination match, Sanada was defeated in the finals of the tournament the following day by Shynron. After leaving TNA in April 2015, Sanada began working more regularly on the American independent circuit. On May 6, Global Force Wrestling (GFW) announced Sanada as part of their roster. He made his debut for the promotion on July 11, teaming with Takaaki Watanabe in a tag team match, where they were defeated by Bullet Club (Doc Gallows and Karl Anderson). Though now living in the United States, in July Sanada flew back to Japan to take part in a WWE tryout held by William Regal. In August 2016, Sanada teamed with Minoru Fujita and Mazada to defeat the team of Harashima, Kotaro Suzuki and Masato Tanaka at a Tokyo Gurentai event.
On April 10, 2016, Sanada, sporting a new look including a mohawk, made a surprise debut for NJPW at Invasion Attack 2016 by interfering in the main event and helping Tetsuya Naito defeat Kazuchika Okada for the IWGP Heavyweight Championship, joining Naito's Los Ingobernables de Japon (L.I.J.) stable in the process. The following day, NJPW announced Sanada's new ring name; his family name stylized in all capital letters. Though he started working for NJPW full-time, Sanada remained a freelancer. Sanada wrestled his first NJPW match on April 17, when he and his L.I.J. stablemates Naito, Bushi and Evil defeated Gedo, Hirooki Goto, Kazuchika Okada and Tomohiro Ishii with him submitting Gedo for the win. Sanada's first big match in NJPW took place on May 3 at Wrestling Dontaku 2016, where he was defeated by Okada. On July 18, Sanada entered the 2016 G1 Climax, opening his tournament by scoring a major win over Hiroshi Tanahashi. He finished the tournament on August 12 with a record of four wins and five losses. At the end of the year, Sanada took part in the 2016 World Tag League, teaming with stablemate Evil. The two finished second in their block with a record of five wins and two losses, tied with block winners Togi Makabe and Tomoaki Honma, but failed to advance to the finals due to losing the head-to-head match against Makabe and Honma. On January 4, 2017, at Wrestle Kingdom 11 in Tokyo Dome, Sanada, Bushi and Evil won a four-team gauntlet match to become the new NEVER Openweight 6-Man Tag Team Champions. They lost the title to Hiroshi Tanahashi, Manabu Nakanishi and Ryusuke Taguchi the next day, before regaining it on February 11 at The New Beginning in Osaka. They lost the title to Tanahashi, Taguchi and Ricochet in their second defense on April 4, before regaining it on May 3 at Wrestling Dontaku 2017. During the summer, Sanada took part in the 2017 G1 Climax, where he finished with a record of four wins and five losses.Finishing moves
Bridging tiger suplex
Moonsault Press (AJPW) / Rounding Body Press (NJPW/W-1) (Moonsault) – adopted from Keiji Mutoh
Skull End (NJPW) / This Is It (AJPW/W-1) (Dragon sleeper with bodyscissors) – 2012–present
Superkick to a kneeling opponent – TNA
Bridging dragon suplex
Green mist – TNA
Japanese leg roll clutch
Missile dropkick, sometimes while springboarding
Paradise Lock (Over-rotated Delfin Clutch) – 2017–present; adopted from Milano Collection A.T.
TKO (Fireman's carry cutter)
"Seishun Hurricane" (Japanese for "Youth Hurricane")
"Seishun no Arashi (Hurricane)" by Hiroyuki Sanada
"Probability" by All Japan Pro Wrestling
"Japan Rising Sun" by Dale Oliver (TNA)
"Cold Skeleton" by Yonosuke Kitamura
All Japan Pro Wrestling
All Asia Tag Team Championship (2 times) – with Manabu Soya
Gaora TV Championship (1 time)
World Tag Team Championship (1 time) – with Joe Doering
Gaora TV Championship Tournament (2012)
Samurai! TV Cup Triple Arrow Tournament (2007) – with Kensuke Sasaki and Katsuhiko Nakajima
World's Strongest Tag Determination League (2011) – with Kai
New Japan Pro-Wrestling
NEVER Openweight 6-Man Tag Team Championship (3 times, current) – with Bushi and Evil
Pro Wrestling Illustrated
PWI ranked him #66 of the top 500 singles wrestlers in the PWI 500 in 2014
Total Nonstop Action Wrestling
TNA X Division Championship (1 time)
Global Impact Tournament (2015) – with (Angelina Love, Bram, Drew Galloway, The Great Muta, Khoya, Magnus, Rockstar Spud, Sonjay Dutt and Tigre Uno)