People of the surname Saussure or de Saussure include
Horace-Bénédict de Saussure (1740–1799), Swiss physicist and Alpine traveller
Nicolas-Théodore de Saussure (1767–1845), chemist, son of Horace-Bénédict, and brother of Albertine
Albertine Necker de Saussure (1766–1841), Swiss writer, educationalist, and advocate of education for women, daughter of Horace-Bénédict, and sister of Nicolas-Théodore
Henri Louis Frédéric de Saussure (1829–1905), Swiss mineralogist and entomologist (taxonomist), and father of Ferdinand, Léopold and René.
Ferdinand de Saussure (1857–1913), Swiss linguist, brother of Léopold and René
Léopold de Saussure (1866–1925), sinologist, astronomer, French Naval Officer, brother of Ferdinand and René
René de Saussure (1868–1943), Swiss Esperantist and scientist, brother of Ferdinand and Léopold
Hermine de Saussure (1901–1984), female sailing pioneer and scholar, specialist of Jean-Jacques Rousseau daughter of Léopold and mother of Delphine Seyrig
Éric de Saussure (1925–2007), Swiss artist and member of the Taizé Community
Henry William de Saussure (1763–1839) American lawyer, State legislator from South Carolina, President of the U.S. Mint
William F. De Saussure (1792–1870), U.S. Senator from South Carolina