Notable people with the surname include:
Abe Saperstein (1902–1966), founder and coach of the Savoy Big Five, which later became the Harlem Globetrotters
Alan Saperstein, Internet Video Pioneer and digital media entrepreneur
David I Saperstein, Jewish American entrepreneur
David Saperstein (disambiguation)
Esther Saperstein (1901-1988), American politician
Harlan Saperstein, television narrator of several E! True Hollywood Story and History Channel documentaries
Fictional entities with the surname include:
Dr. Saperstein, a fictional obstetrician in Parks and Recreation, played by Henry Winkler
Jean-Ralphio Saperstein, a fictional character in Parks and Recreation, played by Ben Schwartz
Mona Lisa Saperstein, a fictional character in Parks and Recreation, played by Jenny Slate
