Notable people with the surname include:
Abe Saperstein (1902–1966), founder and coach of the Savoy Big Five, which later became the Harlem GlobetrottersAlan Saperstein, Internet Video Pioneer and digital media entrepreneurDavid I Saperstein, Jewish American entrepreneurDavid Saperstein (disambiguation)Esther Saperstein (1901-1988), American politicianHarlan Saperstein, television narrator of several E! True Hollywood Story and History Channel documentariesFictional entities with the surname include:
Dr. Saperstein, a fictional obstetrician in Parks and Recreation, played by Henry WinklerJean-Ralphio Saperstein, a fictional character in Parks and Recreation, played by Ben SchwartzMona Lisa Saperstein, a fictional character in Parks and Recreation, played by Jenny Slate