Santucci is a surname of Italian origin.
It may refer to:
Angelo Santucci (born 1952), Canadian Football League player
Barbara Santucci (born 1947), American artist, poet and author
Dan Santucci (born 1983), American football player
John J. Santucci (born 1931), New York politician, D.A. of Queens County
Michele Santucci (born 1989), Italian Olympic swimmer
Nico Santucci (born 1962), Italian-American restaurateur, entrepreneur and designer
Pat Santucci (1924–1992), Canadian football player
Roberto Santucci (born 1967), Brazilian filmmaker
Serge Santucci (born 1944, French sculptor and medallist
Vincenzo Santucci (1796–1861), Italian Roman Catholic cardinal