Santana is a Latin surname, most common in Spanish speaking countries:
Carlos Santana (born 1947), Mexican-American guitarist
Luan Santana (born 1991), Brazilian singer
Jorge Santana (born 1951), musician and brother of Carlos Santana
Salvador Santana (born 1983), musician and son of Carlos Santana
Juelz Santana (born 1982), rapper
Johan Santana (born 1979), pitcher in Major League Baseball
Ervin Santana (born 1982), Major League Baseball Pitcher for the Minnesota Twins
Pedro Santana (1801–1864), first President of the Dominican Republic
Rodrigão (Rodrigo Santana, born 1979), Brazilian volleyball player
Tito Santana (born 1953), professional wrestler
Manuel Santana (born 1938), tennis player
Lizé Santana (born 1980), American singer-songwriter
