Santana is a Latin surname, most common in Spanish speaking countries:
Carlos Santana (born 1947), Mexican-American guitaristLuan Santana (born 1991), Brazilian singerJorge Santana (born 1951), musician and brother of Carlos SantanaSalvador Santana (born 1983), musician and son of Carlos SantanaJuelz Santana (born 1982), rapperJohan Santana (born 1979), pitcher in Major League BaseballErvin Santana (born 1982), Major League Baseball Pitcher for the Minnesota TwinsPedro Santana (1801–1864), first President of the Dominican RepublicRodrigão (Rodrigo Santana, born 1979), Brazilian volleyball playerTito Santana (born 1953), professional wrestlerManuel Santana (born 1938), tennis playerLizé Santana (born 1980), American singer-songwriter