Species Human Entrez 6857 | Human Mouse Ensembl ENSG00000067715 | |
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Aliases SYT1, P65, SVP65, SYT, synaptotagmin 1 External IDs MGI: 99667 HomoloGene: 4122 GeneCards: SYT1 | ||
Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.
Contents
Function
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001).[supplied by OMIM]
SYT1 is the master switch responsible for allowing the human brain to release neurotransmitters. SYT1 senses calcium concentrations as low as 10 ppm and subsequently signals the SNARE complex to open fusion pores.
Interactions
SYT1 has been shown to interact with SNAP-25, STX1A and S100A13.
References
SYT1 Wikipedia(Text) CC BY-SA