SUV39H1

Updated on Dec 11, 2024

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Species Human Entrez 6839		Human Mouse Ensembl ENSG00000101945

Aliases SUV39H1, H3-K9-HMTase 1, KMT1A, MG44, SUV39H, suppressor of variegation 3-9 homolog 1 External IDs MGI: 1099440 HomoloGene: 2388 GeneCards: SUV39H1

Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.

Function

This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.

SUV39H1 has been shown to interact with:

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