SUPT7L

Model organisms

Model organisms have been used in the study of SUPT7L function. A conditional knockout mouse line, called Supt7l^{tm1a(EUCOMM)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and two significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice but no further abnormalities were observed.

Interactions

SUPT7L has been shown to interact with TAF9 and Transcription initiation protein SPT3 homolog.