Species Human Entrez 11198 | Human Mouse Ensembl ENSG00000092201 | |
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Aliases SUPT16H, CDC68, FACTP140, SPT16/CDC68, SPT16, SPT16 homolog, facilitates chromatin remodeling subunit External IDs MGI: 1890948 HomoloGene: 5207 GeneCards: SUPT16H | ||
FACT complex subunit SPT16 is a protein that in humans is encoded by the SUPT16H gene.
Contents
Function
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is the protein encoded by this gene.
Interactions
SUPT16H has been shown to interact with BAZ1B.
References
SUPT16H Wikipedia(Text) CC BY-SA