Entrez 387082 | Ensembl ENSG00000177688 | |
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Aliases SUMO4, IDDM5, SMT3H4, SUMO-4, dJ281H8.4, small ubiquitin-like modifier 4 External IDs HomoloGene: 88399 GeneCards: SUMO4 | ||
Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene.
Contents
Function
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.
Interactions
SUMO4 has been shown to interact with IκBα.
References
SUMO4 Wikipedia(Text) CC BY-SA