Species Human Entrez 55959 | Human Mouse Ensembl ENSG00000196562 | |
Aliases SULF2, HSULF-2, sulfatase 2 External IDs MGI: 1919293 HomoloGene: 10313 GeneCards: SULF2 | ||
Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.
Function
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM]
References
SULF2 Wikipedia(Text) CC BY-SA