Symbol SUI1 InterPro IPR001950 SCOP 2if1 | Pfam PF01253 PROSITE PDOC00862 SUPERFAMILY 2if1 | |
 | ||
In molecular biology, the protein domain SUI1 is a translation initiation factor often found in the fungus, Saccharomyces cerevisiae (Baker's yeast) but it is also found in other eukaryotes and prokaryotes as well as archaea.
Contents
Function
SUI1 is a translation initiation factor directs the ribosome to the translation start site, helped by eIF-2 and the initiator tRNA-Met. SUI1 ensures that there is the start codon, AUG, in the beginning of the protein which helps stabilise the pre-initiation complex. SUI1 has such a high fidelity for AUG, that it discriminates against non-AUG codons. This protein is vital for finding the correct initiation site. This ultimately aids the formation of the pre-initiation complex.
Structure
The primary structure of the SUI1 protein is made up of 108 amino acids. The protein domain has a structure made of a seven-bladed beta-propeller and it also contains a C-terminal alpha helix. Homologuess of SUI1 have been found in mammals, insects and plants. SUI1 is also evolutionary related to hypothetical proteins from Escherichia coli (yciH), Haemophilus influenzae (HI1225) and Methanococcus vannielii.