Entrez 51684 | Ensembl ENSG00000107882 | |
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Aliases SUFU, PRO1280, SUFUH, SUFUXL, SUFU negative regulator of hedgehog signaling External IDs MGI: 1345643 HomoloGene: 9262 GeneCards: SUFU | ||
Function
SUFU encodes a component of the sonic hedgehog (SHH) / patched (PTCH) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., holoprosencephaly, HPE3; basal cell nevus syndrome, BCNS; and Greig cephalopolysyndactyly syndrome; GCPS).
Interactions
References
SUFU Wikipedia(Text) CC BY-SA