Species Human Entrez 134957 | Human Mouse Ensembl ENSG00000164506 | |
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Aliases STXBP5, LGL3, LLGL3, Nbla04300, syntaxin binding protein 5 External IDs MGI: 1926058 HomoloGene: 16402 GeneCards: STXBP5 | ||
Syntaxin-binding protein 5 is a protein that in humans is encoded by the STXBP5 gene.
Contents
Function
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced variants have been identified, but their biological validity has not been determined.
Interactions
STXBP5 has been shown to interact with STX4 and STX1A.
References
STXBP5 Wikipedia(Text) CC BY-SA