CAS Number 1354631-26-7 ChemSpider 28189067 3D model (Jmol) Interactive image | PubChem CID 57404059 Formula C24H31FN2O Molar mass 382.51 g/mol | |
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Legal status CA: Schedule II
DE: Anlage II (Prohibited)
NZ: Temporary Class | ||
STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to utilise an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144. STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors. STS-135 produces bradycardia and hypothermia in rats at doses of 1–10 mg/kg, suggesting cannabinoid-like activity.
Contents
Legal Status
As of October 2015 STS-135 is a controlled substance in China.
Detection
A forensic standard of STS-135 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.