Entrez 6773 | Ensembl ENSG00000170581 | |
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Aliases STAT2, ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2 External IDs MGI: 103039 HomoloGene: 3952 GeneCards: STAT2 | ||
Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family.
Contents
Function
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
Interactions
STAT2 has been shown to interact with: