Girish Mahajan (Editor)

STAP1

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Covid-19
Species  Human
Entrez  26228
Human  Mouse
Ensembl  ENSG00000035720
STAP1
Aliases  STAP1, BRDG1, STAP-1, signal transducing adaptor family member 1
External IDs  MGI: 1926193 HomoloGene: 8103 GeneCards: STAP1

Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.

Contents

Function

The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.

Interactions

STAP1 has been shown to interact with C19orf2.

References

STAP1 Wikipedia


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