Entrez 26228 | Ensembl ENSG00000035720 | |
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Aliases STAP1, BRDG1, STAP-1, signal transducing adaptor family member 1 External IDs MGI: 1926193 HomoloGene: 8103 GeneCards: STAP1 | ||
Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.
Contents
Function
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.
Interactions
STAP1 has been shown to interact with C19orf2.
References
STAP1 Wikipedia(Text) CC BY-SA