Entrez 10254 | Ensembl ENSG00000115145 | |
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Aliases STAM2, Hbp, STAM2A, STAM2B, signal transducing adaptor molecule 2 External IDs MGI: 1929100 HomoloGene: 68490 GeneCards: STAM2 | ||
Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene.
Contents
Function
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
Interactions
STAM2 has been shown to interact with HGS, Janus kinase 1{ and USP8.
References
STAM2 Wikipedia(Text) CC BY-SA