Species Human Entrez 6732 | Human Mouse Ensembl ENSG00000096063 | |
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Aliases SRPK1, SFRSK1, SRSF protein kinase 1 External IDs MGI: 106908 HomoloGene: 110962 GeneCards: SRPK1 | ||
Serine/threonine-protein kinase SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.
Contents
Function
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined.
Possible anti-cancer target
Some cancers are vascular endothelial growth factor (VEGF) dependant (for angiogenesis). SRPK1 activates (phosphorylates) VEGF splicing factor. SRPK1 inhibitors (e.g. 'SPHINX compounds' ) are being investigated as treatments for prostate cancer.
SRPK1 enables angiogenesis, which is regulated by VEGF, which either initiates or inhibits vessel formation depending on alternative splicing. In human prostate cancer, levels of SRPK1 rose as a cancer becomes more aggressive. In a mouse model three doses per week of drugs designed to inhibit SRPK1 activity inhibitef tumor vasculature and growth.
Interactions
SRPK1 has been shown to interact with: