Species Human Entrez 81848 | Human Mouse Ensembl ENSG00000187678 | |
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Aliases SPRY4, HH17, sprouty RTK signaling antagonist 4 External IDs MGI: 1345144 HomoloGene: 8042 GeneCards: SPRY4 | ||
Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.
Contents
Function
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[supplied by OMIM]
Interactions
SPRY4 has been shown to interact with TESK1.
References
SPRY4 Wikipedia(Text) CC BY-SA