Symbol SPR InterPro IPR007875 PDB RCSB PDB; PDBe; PDBj | Pfam PF05210 Pfam structures PDBsum structure summary | |
In molecular biology the SPR domain is a protein domain found in the Sprouty (Spry) and Spread (Sprouty related EVH1 domain) proteins. These have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential. It also mediates homodimer formation of these proteins.
The SPR domain can occur in association with the WH1 domain (see InterPro: IPR000697) (located in the N-terminus) in the Spread proteins.
Examples
Human genes encoding protein containing the SPR domain include: