Species Human Entrez 6664 | Human Mouse Ensembl ENSG00000176887 | |
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Aliases SOX11, MRD27, SRY-box 11 External IDs MGI: 98359 HomoloGene: 37733 GeneCards: SOX11 | ||
Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.
Contents
Function
This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis. Tuj1 and Tead2 are suggested as direct target of Sox11.
Clinical aspect
Mutations in SOX11 are associated to Coffin-Siris syndrome .
References
SOX11 Wikipedia(Text) CC BY-SA