Supriya Ghosh (Editor)

SOD3

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Covid-19
Species  Human
Entrez  6649
Human  Mouse
Ensembl  ENSG00000109610
SOD3
Aliases  SOD3, EC-SOD, superoxide dismutase 3, extracellular
External IDs  MGI: 103181 HomoloGene: 2334 GeneCards: SOD3

Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene.

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.

References

SOD3 Wikipedia


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