Entrez 6646 | Ensembl ENSG00000057252 | |
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Aliases SOAT1, ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT, sterol O-acyltransferase 1 External IDs MGI: 104665 HomoloGene: 2333 GeneCards: SOAT1 | ||
Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1, also known as SOAT1, is an enzyme that in humans is encoded by the SOAT1 gene.
Contents
Function
Acyl-coenzyme A:cholesterol acyltransferase (EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988).
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
References
SOAT1 Wikipedia(Text) CC BY-SA