Species Human Entrez 55117 | Human Mouse Ensembl ENSG00000072041 | |
Aliases SLC6A15, NTT73, SBAT1, V7-3, hv7-3, solute carrier family 6 member 15 External IDs MGI: 2143484 HomoloGene: 18163 GeneCards: SLC6A15 | ||
Solute carrier family 6 member 15 (SLC6A15) also known as the sodium-dependent neutral amino acid transporter B(0)AT2 (B0AT2)' is a protein that in humans is encoded by the SLC6A15 gene.
Contents
Function
SLC6A15 shows structural characteristics of an Na+ and Cl−-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.
Clinical relevance
Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.
References
SLC6A15 Wikipedia(Text) CC BY-SA