Suvarna Garge (Editor)

SLC4A5

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Species
  
Human

Entrez
  
57835

Human
  
Mouse

Ensembl
  
ENSG00000188687

SLC4A5

Aliases
  
SLC4A5, NBC4, NBCe2, solute carrier family 4 member 5

External IDs
  
MGI: 2443220 HomoloGene: 31125 GeneCards: SLC4A5

Electrogenic sodium bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene.

Contents

Function

This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Clinical significance

This human gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status.

References

SLC4A5 Wikipedia