Species Human Entrez 142680 | Human Mouse Ensembl ENSG00000198569 | |
Aliases SLC34A3, HHRH, NPTIIc, solute carrier family 34 member 3, NaP2b External IDs MGI: 2159410 HomoloGene: 15444 GeneCards: SLC34A3 | ||
Sodium-dependent phosphate transport protein 2C is a protein that in humans is encoded by the SLC34A3 gene.
Contents
Function
SLC34A3 contributes to the maintenance of inorganic phosphate concentration at the kidney.
Interactions
SLC34A3 has been shown to interact with PDZK1.
Clinical Correlation
A mutation in the SLC34A3 gene has been known to cause the autosomal recessive condition hereditary hypophophatemic rickets with hypercalciuria. This gene is correlated closely with SLC34A1, an analogue sodium phosphate cotransporter protein. Symptoms include renal phosphate wasting in addition to increase levels of 1,25-dihydroxyvitamin D (yields the hypercalcuria).
References
SLC34A3 Wikipedia(Text) CC BY-SA