Entrez 4068 | Ensembl ENSG00000183918 | |
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External IDs MGI: 1328352 HomoloGene: 1762 GeneCards: SH2D1A |
SH2 domain–containing protein 1A is a protein that in humans is encoded by the SH2D1A gene. It is often called SLAM-associated protein (symbol SAP), where "SLAM" refers to signaling lymphocytic activation molecules. It is a SH2 domain–containing molecule (part of a family of such molecules) that plays a role in SLAM signaling. A putative function is as an adaptor for Fyn and competitor of phosphatases, leading to modulation of SLAM family function. SAP has been implicated in autoimmunity, and a mutation of it is associated with X-linked lymphoproliferative disease.
References
SH2D1A Wikipedia(Text) CC BY-SA